Job Description

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Company Overview

The people of Memorial Sloan Kettering Cancer Center (MSK) are united by a singular mission: ending cancer for life. Our specialized care teams provide personalized, compassionate, expert care to patients of all ages. Informed by basic research done at our Sloan Kettering Institute, scientists across MSK collaborate to conduct innovative translational and clinical research that is driving a revolution in our understanding of cancer as a disease and improving the ability to prevent, diagnose, and treat it. MSK is dedicated to training the next generation of scientists and clinicians, who go on to pursue our mission at MSK and around the globe.

Job Description

Exciting opportunity at Memorial Sloan Kettering Cancer Center :

Are you passionate about ground breaking research and advancing cancer treatment? Our Gene Editing and Screening Core Facility is seeking a Research Assistant to support small molecule high-throughput screening (HTS) and high-content cell-based screening (HCS) for MSK researchers and other academic institutions. Arrayed small molecule and siRNA libraries, along with pooled functional genomics CRISPR-Cas9 and shRNA libraries, are offered for such screens. Core services include: assay development, performing large screens, data analysis, hit calling, confirmation and validation of hits, statistical calculations, dose response curves, drug and radiation synergies, synthetic lethality, and signaling pathway associations.

If you're eager to be part of a world-renowned research institution and make a tangible impact on cancer treatment, apply today!

Role Overview:

• Develop cell-based and non- cell-based assays for HTS and HCS screens.
• Perform arrayed small molecule screening experiments, full genome siRNA knockdown and CRISPR-Cas9 KO in a 96/384 well high-throughput screening format.
• Acquire large-scale image / screening data and perform Hiseq deconvolution analysis.
• Collect and enter data, assist in analyzing data, preparation of reports and manuscripts.
• Maintain and develop protocols for laboratory automation including chemical inventory.
• Attend and participate in project meetings, assist in preparing and conducting experiments following established procedures or protocols, summarize results of experiments performed, and assist in interpreting the results of studies.
• Assist with maintaining, testing and/or implementation of robotics and automation.

Key Qualifications :

• B.S. in biology (molecular, cell, pharmacology) or related field with 4 years of relevant experience, or M.S. with 2-4 years of experience.
• Proven expertise with large scale sterile cell culture.
• 1-3 years of experience in running microscopy-based studies.
• Experience in advanced image analysis, RNAi and CRISPR-Cas9 techniques.
• Proficiency in managing high-end laboratory robotics and instrumentation.
• Strong background in HCS and HTS assay development (biochemical and cell-based).

Core Skills:

• Exceptional attention to detail and strong analytical skills.
• Ability to thrive in a fast-paced research environment, managing multiple projects while maintaining precision.
• Critical thinking and problem-solving skills to troubleshoot experimental challenges.
• Outstanding interpersonal and communication skills and the ability to interact across all levels in a confident, concise, professional manner.
• Enthusiasm and dedication to MSK's vision, mission and values.

Additional Information:

• Location: Zuckerman, 417 E 68th Street, NYC
• Schedule: 37.5 hours per week (onsite)

Pay Range: $66,500 - $103,100

Helpful Links :

• MSK Compensation Philosophy
• Review our great benefits offerings
• Gene Editing and Screening Core Facility

Closing

MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision.

Federal law requires employers to provide reasonable accommodation to qualified individuals with disabilities. Please tell us if you require a reasonable accommodation to apply for a job or to perform your job. Examples of reasonable accommodation include making a change to the application process or work procedures, providing documents in an alternate format, using a sign language interpreter, or using specialized equipment.

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